تالیفات

 

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

مولف: Joana M Xavier1, 2, Fereydoun Davatchi3, Olga Abade4, Farhad Shahram3, Vânia Francisco1, 2, Bahar Sadeghi Abdollahi3, Hélder Trindade4, Abdolhadi Nadji3, Niloofar Mojarad Shafiee3, Fahmida Ghaderibarmi3, Dário Ligeiro4 and Sofia A Oliveira1, 2*

خلاصه: Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case–control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B ... سال انتشار: 2015
 

Iron deficiency state in resistant oral aphthosis of Behcet’s disease

Authers: Taraneh DORMOHAMMADI TOOSI, 1 Farhad SHAHRAM, 1 S. Zahra GHODSI, 2 Abdolhadi NADJI, 1 Arash TEHRANI BANIHASHEMI, 1 Seyyedeh Roghieh LARIMI1 and Fereydoun DAVATCHI1

Abstract: Aim: This study was designed to evaluate iron deficiency as a predisposing factor for resistant oral aphthosis in patients with Behcet’s disease (BD). Methods: In a case control study 220 consecutive BD patients with oral aphthosis were enrolled. All patients had been treated for at least 3 months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group). Demographic and clinical characteristics ... سال انتشار: 2014
 

Clinical features of Behcet ’ s disease in patients without oral aphthosis

Authers: Seyedeh Tahereh Faezi 1 , Pedram Paragomi 1 , Farhad Shahram 1 , Hormoz Shams 2 , Cheida Shams-Davatchi 3 , Zahra Ghodsi 3 , Abdolhadi Nadji 1 , Maassoumeh Akhlaghi 1 , and Fereydoun Davatchi 1

Abstract: In current study we evaluated clinical features of Behcet ’ s Disease (BD) in patients without oral aphthosis (NOA cases). Methods. In a cohort of BD, patients registered during a period of 36 years were collected. We determined clinical features of BD NOA cases and compared them with patients with oral aphthosis (OA cases). The comparison was performed by chi square and Fischer ’ s exact test. Results. Among 6821 BD patients, 175 patients (2.56%) ... سال انتشار: 2013
 

Iron deficiency state in resistant oral aphthous of Behcet’s disease

Authers: Taraneh DORMOHAMMADI TOOSI, 1 Farhad SHAHRAM, 1 S. Zahra GHODSI, 2 Abdolhadi NADJI, 1 Arash TEHRANI BANIHASHEMI, 1 Seyyedeh Roghieh LARIMI1 and Fereydoun DAVATCHI1

Abstract: This study was designed to evaluate iron deficiency as a predisposing factor for resistant oral aphthosis in patients with Behcet’s disease (BD). Methods: In a case control study 220 consecutive BD patients with oral aphthosis were enrolled. All patients had been treated for at least 3 months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group). Demographic and clinical characteristics of ... سال انتشار: 2013
 

Fc-Gamma Receptor 3B Copy Number Variation Is Not a Risk Factor for Behc¸et’sDisease

Authers: Rachel Black, 1 Sue Lester, 1 Emma Dunstan, 1 Farhad Shahram, 2 Abdolhadi Nadji, 2 Noushin Bayat, 2, 3 Kayvan Saeedfar, 2, 4 Naghmeh Ziaei, 2 Catherine Hill, 1, 5 Maureen Rischmueller, 1, 5 and Fereydoun Davatchi2

Abstract: Behc¸et’s disease (BD) is an immune-mediated systemic vasculitis associated with HLAB51. Other gene associations are likely and may provide further insight into the pathogenesis of this disease. Fc-gamma receptors play an important role in regulating immune function. Copy number variation (CNV) of the Fc-gamma receptor 3B (FCGR3B) gene is associated with other inflammatory conditions and may also play a role in BD. The aim of this study was to determine whether CNV of ... سال انتشار: 2012
 

Association Study of IL10 and IL23R–IL12RB2 in Iranian Patients With Behc¸et’s Disease

Authers: Joana M. Xavier, 1 Farhad Shahram, 2 Fereydoun Davatchi, 2 Alexandra Rosa, 3 Jorge Crespo, 4 Bahar Sadeghi Abdollahi, 2 Abdolhadi Nadji, 2 Gorete Jesus, 5 Filipe Barcelos, 6 Jose´ Vaz Patto, 6 Niloofar Mojarad Shafiee, 2 Fahmida Ghaderibarim, 2 and Sofia A. Oliveira1

Abstract: Independent replication of the findings from genome-wide association studies (GWAS) remains the gold standard for results validation. Our aim was to test the association of Behc¸et’s disease (BD) with the interleukin-10 gene (IL10) and the IL-23 receptor–IL-12 receptor 2 (IL23R–IL12RB2) locus, each of which has been previously identified as a risk factor for BD in 2 different GWAS. Methods. Six haplotype-tagging single-nucleotide polymorphisms (SNPs) in IL10 and 42 in IL23R–IL12RB2 were genotyped in 973 Iranian patients with BD and 637 non-BD ... سال انتشار: 2012
 

Plasma Homocysteine Level in Patients with Behcet’s Disease with or without Thrombosis

Authers: Farhad Shahram MD, Alireza Faridar MD1, Mohammad Ghaffari Hamedani MD, Abdolhadi Nadji MD1, Nassim Naderi MD, Niloofar Mojarad Shaee BS, Johannes J. Rasker MD, Fereydoun Davatchi MD

Abstract: Aim: To nd the possible role of plasma homocysteine level as a contributing factor in venous and arterial thrombosis in patients with Behcet’s disease (BD). Methods: In a case control study, two groups of BD patients were included: 47 with thrombosis and 49 without thrombosis. All patients fullled the International Study Group Criteria for BD and the conrming diagnostic procedures for vascular thrombosis were either Doppler sonography or angiography. Forty-nine controls were selected by ... سال انتشار: 2010