تالیفات

Survivin and autoimmunity; the ins and outs  

Survivin and autoimmunity; the ins and outs

مولف: Hamidreza Ebrahimiyana, b, Saeed Aslania, Nima Rezaeib, c, d, Ahmadreza Jamshidia, Mahdi Mahmoudia,

خلاصه: Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Apoptosis is one of the important mechanisms in maintaining the tolerance and eliminating the autoreactive lymphocyte ... سال انتشار: 2018
 

EAssociation of Interleukin-2, but notInterferon-Gamma, single nucleotide polymorphismswith juvenile idiopathic arthritisM.

Authers: Maddaha, S. Harsinib, A. Rezaeib, M. Sadrc, S. Zoghid, M.H. Moradinejada, V. Ziaeea, e, N. Rezaei

Abstract: Cytokines, including interleukin-2 (IL-2) and interferon-gamma (IFN-), seem toplay a role in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study wasto investigate the associations of IL-2 and IFN- single nucleotide polymorphisms (SNPs) withsusceptibility to JIA in an Iranian population.Methods: Genomic DNA of 54 Iranian patients with JIA and 139 healthy unrelated controls weretyped for IL-2 (G/T at −330 and +166) as well as IFN- gene (A/T ... سال انتشار: 2016
 

ARTICLEInterleukin-23 receptor single nucleotidepolymorphisms in ulcerative colitis. A studyin Iranian populations

Authers: Nasser Ebrahimi Daryania, Farnaz Najmi Varzanehb, Mona Hedayatc, Mohammad Tahera, Elham Farhadia, d, Mahdi Mahmoudie, Mohammad Hossein Nicknamb, Mohammad Bashashatif, Nima Rezaeib,

Abstract: Background/objective: Genetic factors seem to play an important role in the pathogenesis ofulcerative colitis (UC). Genome wide association studies showed a highly significant associationbetween interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn’sdisease; however, there are contrary results regarding the disease-modifying effects of IL23Rvariants in UC. This study was performed in a group of patients with UC to test the possible roleof IL23R SNPs in conferring susceptibility or protection ... سال انتشار: 2014