Outcome measurement of ocular lesions in Behcet’s disease.


Abstract: The outcome of ocular manifestations of Behcet’s Disease remains uncertain and unpredictable despite cytotxic drugs. One of our recent studies, presented to the 1995 Korean Rheumatology Annual Meeting, showed that one third of patients were None Responders, regardless of what treatment used. This study was designed to search for factors predicting the final outcome at the beginning of the treatment. Patients having more than one year of treatment were selected for the study. A Total Adjusted Disease Activity Index (TADAI) was calculated upon the Visual Acuity (VA) and the inflammatory state of the uvea and the retina. A good outcome was defined as VA not inferior to 4 Snellen and TADAI improved by 20%. The comparison of good and bad outcome was preformed by the Classification and Regression Tree method on 71 parameters. From 655 eyes, 353 had a bad and 182 eyes had a good outcome. The predictor for a bad outcome was a VA inferior to 4 Snellen at the beginning of the treatment. The sensitivity was 79%, the specificity was 100%, and the accuracy 90%.