Abstract: Systemic Lupus Erythematosus (SLE) is a known underlying disease predisposing to salmonellosis. We report here 39 cases of salmonellosis in 30 patients in a population of 897 patients with SLE, during a 17 years period. All were women with a mean age of 25.7 years. Eighty percent were taking prednisolone and 26% cytotoxics at the onset of the infection. Renal involvement was present in 77% (type IV WHO in 65% of them), the same as other SLE patients. Clinical manifestations were as follow: Fever and chills 82%, diarrhea 26%, abdominal pain 20%, septic arthritis 28%, osteomyelitis 8%, pulmonary signs 8% and urinary symptoms 3%. Diagnosis was based upon the isolation of the microorganism in 87% of cases, mostly from blood culture (59%). Salmonella species other than typhi and paratyphi were often responsible. Widal agglutination test was positive in less than half the cases. Recurrence of infection in 27% of the patients and high mortality rate in 23% of them shows a poor prognosis of salmonellosis in SLE. This special picture of salmonellosis In SLE patients hints for a longer period of treatment in them.