microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

خلاصه: Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV- 1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with healthy controls (p < 0.001 for all comparisons). Conclusion: The mentioned miRNAs seem to influence the clinical progression of HIV-1 infection in naive patients. Moreover, determining the profiles of miRNAs involved in the pathogenesis of HIV infection and manipulating these miRNAs could lead to opening a new gate to HIV-1 infection control. First draft submitted: 30 March 2018; Accepted for publication: 19 June 2018; Published online: 2 August 2018 Keywords: HIV-1 •

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