Prevalence and Clinical Investigation of the Behcet’s Disease in Middle East and North Africa: A Systematic Review and Meta-Analysis

خلاصه: Context: This systematic review and meta-analysis was performed to determine the prevalence (by overall relative frequency) and clinical information of the Behcet’s disease in Middle East and north Africa (MENA) and it has an important effect on the health policy and performing complementary studies in future. Evidence Acquisition: We performed this systematic literature review from several databases including PubMed, Scopus and ISI Web of Science according to search strategy with two filters, place (MENA countries) and time (all articles published from Jan 1980 to Jan 2016 were considered). The keywords such as “Behcet’s syndrome”, “Behcet’s disease”, “triple symptom complex”, “Middle East” were searched. Out of 4013 relevant articles and according to inclusion and exclusion criteria, 28 papers were selected to study. To examine the quality of the studies, all papers were evaluated independently by two authors and the Kappa coefficient was 95%. Afterwards, the critical appraisal was performed by strengthening the reporting of observational studies in epidemiology (STROBE) form. Due to sever heterogeneity, the pooled prevalence (per 100,000 people) was derived by the random effect model that takes between-study variation into account.