EAssociation of Interleukin-2, but notInterferon-Gamma, single nucleotide polymorphismswith juvenile idiopathic arthritisM.


Abstract: Cytokines, including interleukin-2 (IL-2) and interferon-gamma (IFN-), seem toplay a role in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study wasto investigate the associations of IL-2 and IFN- single nucleotide polymorphisms (SNPs) withsusceptibility to JIA in an Iranian population.Methods: Genomic DNA of 54 Iranian patients with JIA and 139 healthy unrelated controls weretyped for IL-2 (G/T at −330 and +166) as well as IFN- gene (A/T at +874), using polymerasechain reaction with sequence-specific primers method, and compared between patients andcontrols.Results: A significantly higher frequency of the IL-2 −330 GG genotype (p < 0.01) was foundin the JIA patients compared to the controls. However, the GT genotype at the same positionwas notably lower than in controls (p < 0.01). Moreover, IL-2 (−330, +166) GT haplotype wasmore frequent in patients with JIA in comparison with controls. No significant differences wasobserved between the two groups of case and control for IL-2 (G/T at +166) and IFN- (A/T at+874) SNPs.Conclusion: The results of the current study suggest that certain SNPs of IL-2 gene have asso-ciation with individuals’ susceptibility to JIA. However, further investigations are required toconfirm the results of this study.© 2016 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.




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