ARTICLEInterleukin-23 receptor single nucleotidepolymorphisms in ulcerative colitis. A studyin Iranian populations

Abstract: Background/objective: Genetic factors seem to play an important role in the pathogenesis ofulcerative colitis (UC). Genome wide association studies showed a highly significant associationbetween interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn’sdisease; however, there are contrary results regarding the disease-modifying effects of IL23Rvariants in UC. This study was performed in a group of patients with UC to test the possible roleof IL23R SNPs in conferring susceptibility or protection against the disease.Methods: The study was performed on 67 Iranian adult patients with UC and 78 healthy controls.Eight IL23R SNPs were genotyped, using real-time polymerase chain reaction (RT-PCR). Thefrequencies of alleles and genotype at each position were determined and compared betweentwo groups of patients and controls.