Abstract: Systemic lupus erythmatous (SLE) is a disease of unknown etiology with wide variety of clinical and immunological features. Our objective was to describe the clinical manifestation and laboratory data in Iranian male patients. Methods: 2279 patients were entered in a cross sectional study. The data were collected from rheumatologic research center in Shariati hospital of Tehran University. The prevalence of clinical and immunological features were compared between male and female patients Results: 227 patients (9.7%) were male and 2052 (90.3%) patients were female. A higher frequency of discoid rash and urine casts and a lower frequency of arthritis and leucopenia were demonstrated in our male patients (P<0.05). The main features were not significantly alike. Conclusion: Incidence of coetaneous manifestation and lower incidence of arthritis in men as well as higher frequency of vital organ involvement such as kidney disease in male patients should be considered in clinical judgment and treatment planning. Key words: Autoimmune Diseases - Lupus Erythematosus, Systemic - Nephritis