EVALUATION OF IL1- AND TNF- SERUM LEVELS IN RHEUMATOID ARTHRITIS PATIONTS WITH ACTIVE AND INACTIVE, WITH OR WITHOUT BONE EROSION


Abstract: Abstract- Rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. Several studies in recent years were conducted for evaluation of inflammatory cytokines such as IL1-& (Interleukin 1&) and TNF- & (Tumor necrosis factor) in rheumatologic disorders including rheumatoid arthritis to find new treatment methods base to pathogenesis. In this study different serum levels of IL1-& and TNF- & in 160 rheumatoid arthritis patients with active and inactive disease and also disease with or without bone erosion are assessed. 4% of our patients had rheumatoid nodule and 70% of all patients had positive RF, IL1-&, and TNF- & levels. Active with bone erosion patients had IL1-& and TNF- & serum levels higher than active without bone erosion patients; it was not significant in Ttest but it was significant in Mann-Whitney Test. The results was the same as expected; IL1-&, and TNF- & serum levels were higher in active with bone erosion in comparison with inactive without bone erosion patients. © 2007 Tehran University of Medical Sciences. All rights reserved. Acta Medica Iranica, 45(6): 487-492; 2007 Key words: Rheumatoid arthritis, erosion, cytokines