THE INFLUENCE OF SEX ON THE SEVERITY AND THE OUTCOME OF EYE LESIONS IN BEHCET’S DISEASE.


Abstract: Introduction: Ocular manifestations are seen more frequently in men than women (62% men, 49% women). The difference is statistically significant (p<00001). It is said that Behcet’s manifestations are more severe in men than women. The aim of this study was to check it in ocular manifestations and to see if the outcome was different in men and women. Materials and Methods: All Behcet’s patients of the treatment registry (1274 at January 20, 2002) entered the study. The visual acuity (VA), the inflammatory index of anterior uveitis (AU), posterior uveitis (PU), and retinal vasculitis (RV) were compared in men and women by the Student t test. Results: Both groups were similar for the mean duration of the eye disease (33 months men/32.9 months women) and the mean treatment time (18.5 months men/20.6 months women). The mean VA before the treatment was 3.6 in men and 4.2 in women (3.6/4.2), the difference was significant (p=0.0012). After the treatment they improved significantly (4.4/5.2). The result for AU was 2.5/2.4 (p=0.51) before the treatment and 0.8/0.7 after the treatment. For PU the result was 2.1/2.0 (p=0.20) before the treatment and 1.0/0.8 after the treatment. For RV the result was 2.5/2.3 (p=0.19) before the treatment and 1.5/1.4 after the treatment. All parameters improved significantly in both groups after the treatment. Conclusion: The only statistically significant difference between the two sexes was in the visual acuity before the treatment. There was no difference in the treatment response in any of the calculated parameters between men and women.