Ocular Lesions Of Behcet's Disease.


Abstract: Objectives: The ocular manifestations of Behcet's disease (BD) are very frequent involving approximately 60% of BD patients. These lesions consist mainly of uveitis (anterior, posterior, or panuveitis that are present in almost all the BD patients with ocular involvement) and necrotizing vasculitis of the retina. In a randomized survey carried on 1812 patients with Ocular-Behcet the prevalence of different ocular signs were as follow: Hypopion 8.7%, glaucoma 8.5%, cataract 70%, intermediate uveitis 6.2%, macular edema 83.7%, periphlebitis and periarteritis of the retina each in 68.7%, retinal arterial necrosis in 38.7%, retinal vein necrosis 35%, macular scar 63.7%, foci of retinitis 17.5%, discal edema 10%, neovascularization 2.5%. In another randomized study on 245 BD patients at the same center retinal vasculitis was reported in 81.2% of patients. It was more frequent in adults compared to the juvenile group (p<0.05), and significantly more in adult males than females (p<0.001). The outcome of the visual prognosis was more threatening in the adult males. In the past the prognosis of ocular lesions of BD had been very poor, and most untreated patients became blind in few years. In the past two decades due to special attention on the treatment of these lesions, a great change has been occurred.