Abstract: Aim: The aim of this study was to assess the demography of SLE in Iran. Methods: In the past 20 years, each patient referred to the Lupus Unit had a computerized form with 266 items. All patients were followed regularly and the data were updated at each visit. Results: We have seen 1310 SLE patients with the following characteristics: The mean age was 24 years, females 89.5%, males 10.5 %, fever 58%, malar rash 62%. discoid lesions 15%, photosensitivity 51%, oral ulcers 36%, polyarthritis 72%, proteinuria 42%, casts 29%, type IV WHO 55%, Convulsion 13% psychosis 5.4%. pericarditis 10%. Pleuritis/pleuresia 21%. hepatomegalia 10%, splenomegalia 18%, Sjogren: 0.3%, anterior uveitis 0.2%, posterior uveitis 0.8%, retinitis 2%. retinal hemorrahge 1.3%, optic nerve atrophy 1%, leukopcnia 31%. lymphopenia 39%, thrombocytopenia 16%, anemia 48%, hemolytic anemia 4.3%, positive coombs 19%, ESR >100 in 33%, LE cells 63%, FANA 81%. VDRL: 15.4%. anti-Cardiolipin IgG 49%, raised antiDN­A 80%, low CH50 53%, low C3 55%, low C4 61%, RF 33%, CRP 55%. overlap with other collagen disease 15%, and infections 21%. Infection was the commonest cause of death in our SLE patients. Conclusion: 1.There are some differences between Iranian SLE features and western countries. 2. Fever, Malar rash and photosesitivity were more frequent in Iranian patients. while Proteinuria, Pericarditis, Pericardial effusion, Leukopenia, Thrombocytopenia and Hematuria were less frequent. 3. Infections were common in Iranian patients. 4. The most common causes of death were respectively as follow: Infections. Pulmonary. CNS, and renal involvement.