Clinical Features of Behcet’s Disease in Children: A Collaborative Study of 86 cases.

Abstract: We collected retrospectively clinical informations about a large series of 86 patients up to 16y of age, from 4 countries: Turquey (43), France (22), Saudi Arabia (11). Iran (10). All cases were first reviewed then 53 of them were selected according to the criteria of the International study group for BD. Statistical analysis: X2 square test and two tailed Fisher exact test. Descriptive data: males 45, females 41, sex ratio 1.1; mean age at diagnosis: 13y (3-16), mean age at onset: 10y (0-16), mean follow-up: I6y (4-29). Familial history of BD: 12 patients. Buccal aphthosis (96%), genital aphthosis (60%), skin hypersensitivity (57%), arthritis (46%), oligoarticular 20%, polyarticular 10%, arthralgias 16%, anterior uveitis (30%), posterior uveitis (30%), retinal vasculitis (20%) and papillar edema (14%), veinous thrombosis (14%), arterial complications (9%),Neuro-Behcet features (26%). Pediatric BD includes an equal sex ratio and a relative high rate of familial cases (15%). Uveitis and vascular complications are a little less frequent than in adults however multiple thrombosis are more likely to be observed in our pediatric population. Male patients experience a more severe course than females with higher risk of uveitis (p<0.001). necrotic folliculitis (p<0.001) and vascular complications. Patients from France and Saudi Arabia have more frequent digestive (p<0.01) and neurological (p<0.01) complications whereas patients from Turkey are more likely to present skin hypersensitivity and erythema nodosum (p<0,001 respectively). The selection of 53 patients: 26 girls, 27 boys, French (11), Turkish (32), Saudi arabians (6), Iranians (4) using the international criteria did not significantly modify the clinical pattern of BD and we wonder these criteria are sufficient.